Diabetes is mainly managed by the patient; a large amount of biomedical knowledge beside clinical, technical and data interpretation skills must be acquired in order for the patient to successfully self-manage diabetes. Currently, we have various technologies and media to represent biomedical knowledge. However, diabetes knowledge is dispersed, weakly structured, hard to find or access, or inefficiently utilizes the Internet. Therefore, a universal and comprehensive web-based knowledge portal for diabetics, healthcare professionals, and the interested general public is needed. In such knowledge portal, biomedical information should be delivered via the easiest and most effective means such as knowledge navigation maps, and biomedical simulation and animation. Moreover, an operational diabetes information portal may provide organizational and implementation models in building biomedical information portals for other diseases and health concerns such as obesity and heart disease. For the last eighteen months, we have been developing the biomedical informatics foundations and concepts for the Diabetes Information Portal. The vision of the Diabetes Information Portal (DIP) is to interconnect diabetes databases, diabetes care services and providers, and diabetics and their medical records via the World Wide Web. The portal serves as a source for credible diabetes data and knowledge, decision support tools, patient management tools and resources, and periodical evaluations for diabetes products like point-of-care biomedical tools and diagnostic and monitoring devices. Electronic educational materials, such as software programs, video games, biomedical animation and simulations, graphs, information maps, and electronic management templates, are available to consumers in one credible source. Students specializing in diabetes care are able to utilize credible, up-to-date, and interactive diabetes learning modules. Researchers are able to collaborate on clinical trials. Clinicians are able to access recent guidelines and decision support tools in managing diabetes. Diabetics can self-manage their own health online via encrypted personal diabetes management pages. A 12-year old student will join us in presenting a few components of the Diabetes Information Portal.